Oh man! I was wondering when this show was going to come out!
Speaking as a long Spidey fan, this is AWESOME! I love everything about it! Sure the 4th wall jokes are more of Deadpool's thing, but honestly, didn't Deadpool steal that from Spider-Man in the first place? And I don't see the comparison to Family Guy. That feels like an insult to this show. The Teen Titan and Scott Pilgrim influences I see as a plus though.
All in all, I'm loving this show!! Aunt May is so many kinds of awesome! Stan Lee as the Janitor is just genius! As is having Agent Coulson as the Principle. This show just reminded me how much I love Spider-Man! And I can't wait to see more! "Thwip! Thwip!"